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Retin-a (tretinoin) is a popularly prescribed medicine intended for the treatment of acne that does not respond to other treatment methods. Retin-a should be applied regularly to produce the best results. You need to apply the cream with clean dry fingers on clean dry skin in a thin layer. Try not to oversaturate the skin with this remedy, as otherwise Retin-a cream may get on the skin not affected by acne. You may experience mild irritation when you first apply this medicine. To make sure this symptom is not severe consult your health care provider and in some rare cases some people may be unable to take this drug because of their skin reaction. Do not increase the dosage unless told so by your health care provider – this can lead to skin irritation. If you happen to miss a dose just resume the treatment on the next day. If you are sensitive to any of the ingredients this medicine contains it’s best to avoid taking Retin-a. It’s normal for some skin reactions to occur, just make sure you know the difference between mild and severe side effects of taking Retin-a to take necessary measures if needed. Mild side effects can include the feeling of warmness, burning, redness, itching and dry sin. Such side effects as blistering and severe irritation are to be reported immediately to your health care provider. You may not be able to continue taking Retin-a. A temporary side effect of Retin-A may be the darkening of skin when this medicine is repeatedly applied.